A study on Hydroxychloroquine
Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the role of hydroxychloroquine on respiratory viral loads.
Patients and methods
French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16th, to receive 600mg of hydroxychloroquine daily and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical presentation, azithromycin was added to the treatment. Untreated patients from another center and cases refusing the protocol were included as negative controls. Presence and absence of virus at Day6-post inclusion was considered the end point.
Results
Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms.
Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported of untreated patients in the literature. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination.
Conclusion
Please cite this work as Gautret et al. (2020) Hydroxychloroquine and azithromycin as a treatment of COVID‐19: results of an open‐label non‐randomized clinical trial. International Journal of Antimicrobial Agents – In Press 17 March 2020 – DOI : 10.1016/j.ijantimicag.2020.105949
THE ABOVE TOOK PLACE IN MARSEILLES, FRANCE. PLEASE NOTE THAT IT WAS NOT THE DRUG THAT WAS BEING TESTED BUT 'THE EFFECT OF THE DRUG ON THE PATIENT' HYDROXYCHLOROQUINE HAS BEEN IN EXISTENCE FOR 80 YEARS AND ITS EFFECT ON MALARIA HAS BEEN REMARKABLE. AFTER 89 YEARS ONE WOULD HOPE THAT IT HAD BEEN SUFFICIENTLY TRIED AND TESTED IT IS NOW VERY MUCH UNDER DISPUTE SINCE PRESIDENT TRUMP MENTIIONED IT AS A CURE. BUT THE TRUTH IS THAT IT IS NOW BEING USED ALL OVER THE WORLD AS A CURE FOR COVIC-19. EVEN CHINA USES IT. AND INDIA EXPORTS IT TO 42 COUNTRIES. AUSTRALIA, NEW ZEALAND, AND INDEED ALMOST EVERY COUNTRY EXCEPT PARTS OF THE USA AND ALTHOUGH THE LANCET SOUNDED OFF AGAINST IT IN MARCH IT FOLLOWED THAT UP IN JUNE BY DISMISSING ITS STUDY, PROBABLY IN THE FACE OF THE MOUNTING EVIDENCE. BUT HERE IS THE POINT, HYDROXYCHLOROQUINE WAS NEVER BANNED N THIS COUNTRY, IT IS JUST THAT A WANING CAME NOT TO USE IT IN CASES OF COVID 19. THE ONLY PEOPLE WHO ARE BANING IT ARE IN AMERICA AND AN ORGANSIATION CALLED FDA WHICH IS JUST SIMPLY NONSENSE SINCE THEY NEVER BANNED IT BEFORE COBID-19 BROKE OUT. A VIDEO OF A GROUP OF 'THOSE NASTY RIGHT WING PEOPLE', DOCORS WHO WANT TO PRESCRIBE THE MEDICINE AND ARE COMPLAINING WENT VIRAL ON TWITTER AND FACEBOOK AND IN RESPONSE TEWITTR AND FACEBOOK CLOSED THE VIDEO DOWN, IN THE INTER3ESTS OF 'MISLEADING INFORMATIION WHICH COULD CAUSE HARM TO OTHERS'. THE EXCUSE USED FOR CLOSING DOWN FREE SPEECH. BUT HYDROXOCHLOROQINEIS A PRESCRIBED MEDICINE WHICH CAN ONLY BE GIVEN OUT BY PHARMACISTS UNDER A DOCTOR'S PRESCRIPTION, AND IT HAS NEVER BEEN DESCRIBED AS A POISON. I AM THOROUGHLY ASHAMED OF THE LIES AD DISTORTIONS FROM PEOPLE WE SHOULD BE TRUSTING, OUR POLITICIANS.
Patients and methods
French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16th, to receive 600mg of hydroxychloroquine daily and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical presentation, azithromycin was added to the treatment. Untreated patients from another center and cases refusing the protocol were included as negative controls. Presence and absence of virus at Day6-post inclusion was considered the end point.
Results
Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms.
Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported of untreated patients in the literature. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination.
Conclusion
Please cite this work as Gautret et al. (2020) Hydroxychloroquine and azithromycin as a treatment of COVID‐19: results of an open‐label non‐randomized clinical trial. International Journal of Antimicrobial Agents – In Press 17 March 2020 – DOI : 10.1016/j.ijantimicag.2020.105949
THE ABOVE TOOK PLACE IN MARSEILLES, FRANCE. PLEASE NOTE THAT IT WAS NOT THE DRUG THAT WAS BEING TESTED BUT 'THE EFFECT OF THE DRUG ON THE PATIENT' HYDROXYCHLOROQUINE HAS BEEN IN EXISTENCE FOR 80 YEARS AND ITS EFFECT ON MALARIA HAS BEEN REMARKABLE. AFTER 89 YEARS ONE WOULD HOPE THAT IT HAD BEEN SUFFICIENTLY TRIED AND TESTED IT IS NOW VERY MUCH UNDER DISPUTE SINCE PRESIDENT TRUMP MENTIIONED IT AS A CURE. BUT THE TRUTH IS THAT IT IS NOW BEING USED ALL OVER THE WORLD AS A CURE FOR COVIC-19. EVEN CHINA USES IT. AND INDIA EXPORTS IT TO 42 COUNTRIES. AUSTRALIA, NEW ZEALAND, AND INDEED ALMOST EVERY COUNTRY EXCEPT PARTS OF THE USA AND ALTHOUGH THE LANCET SOUNDED OFF AGAINST IT IN MARCH IT FOLLOWED THAT UP IN JUNE BY DISMISSING ITS STUDY, PROBABLY IN THE FACE OF THE MOUNTING EVIDENCE. BUT HERE IS THE POINT, HYDROXYCHLOROQUINE WAS NEVER BANNED N THIS COUNTRY, IT IS JUST THAT A WANING CAME NOT TO USE IT IN CASES OF COVID 19. THE ONLY PEOPLE WHO ARE BANING IT ARE IN AMERICA AND AN ORGANSIATION CALLED FDA WHICH IS JUST SIMPLY NONSENSE SINCE THEY NEVER BANNED IT BEFORE COBID-19 BROKE OUT. A VIDEO OF A GROUP OF 'THOSE NASTY RIGHT WING PEOPLE', DOCORS WHO WANT TO PRESCRIBE THE MEDICINE AND ARE COMPLAINING WENT VIRAL ON TWITTER AND FACEBOOK AND IN RESPONSE TEWITTR AND FACEBOOK CLOSED THE VIDEO DOWN, IN THE INTER3ESTS OF 'MISLEADING INFORMATIION WHICH COULD CAUSE HARM TO OTHERS'. THE EXCUSE USED FOR CLOSING DOWN FREE SPEECH. BUT HYDROXOCHLOROQINEIS A PRESCRIBED MEDICINE WHICH CAN ONLY BE GIVEN OUT BY PHARMACISTS UNDER A DOCTOR'S PRESCRIPTION, AND IT HAS NEVER BEEN DESCRIBED AS A POISON. I AM THOROUGHLY ASHAMED OF THE LIES AD DISTORTIONS FROM PEOPLE WE SHOULD BE TRUSTING, OUR POLITICIANS.
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